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Application of hydrodynamic forces (flow and pressure) is essential for microvascular engineering in vitro and has an impact on the engineering of “feeder donor vessel” with the ability to supply surrounding tissues for plastic and reconstructive surgery.

Small-diameter vessel equivalents were fabricated, placed within a bioreactor and subjected to pulsatile perfusion. The pulsatile flow was regulated using a custom-tailored control interface for the employed ISMATEC roller pump. With this program, it was possible to adjust the intensity, duration, and intervals of perfusion pulses that could be monitored via a connected pressure transducer in combination with a display unit.